Promethazine and codeine must be employed through pregnancy provided that the prospective advantage justifies the probable possibility towards the fetus.
Small children Postmarketing instances of respiratory despair, such as fatalities, are already reported with usage of promethazine in pediatric patients. Concomitant administration with other respiratory depressants may possibly boost the possibility of respiratory melancholy.
Prescription drug abuse could be the intentional non-therapeutic use of a prescription drug, even after, for its gratifying psychological or physiological outcomes.
Indicators and signs or symptoms of overdosage with promethazine HCl range between delicate melancholy in the central nervous method and cardiovascular process to profound hypotension, respiratory melancholy, unconsciousness, and unexpected Dying.
Make certain you know the way to consider this product or service and what other medicine you must avoid having with it. See also Drug Interactions section. Get clinical enable straight away if any of such quite serious Unwanted effects arise: slow/shallow respiration, unconventional lightheadedness, significant drowsiness/dizziness, difficulty waking up.
A heightened possibility of certain malformations with codeine exposure for instance respiratory malformations, spina bifida and congenital heart defects were claimed in some experiments.
Results on the Cardiovascular Method Codeine produces peripheral vasodilation which may lead to orthostatic hypotension or syncope. Manifestations of histamine release and/or peripheral vasodilation might incorporate pruritus, flushing, purple eyes and sweating and/or orthostatic hypotension.
If the response to an opioid antagonist is suboptimal or only quick in mother nature, administer further antagonist as directed through the merchandise’s prescribing data. The respiratory depressant outcomes of promethazine are usually not reversed by opioid antagonists, which include naloxone.
The next adverse reactions are Promethazine codeine syrup identified through scientific scientific studies, inside the literature, or all through put up-acceptance usage of codeine and/or promethazine.
Know the signs and symptoms of the overdose, like issues respiratory, staying unusually worn out or sleepy, or not having the ability to respond or awaken. Make sure you tell caregivers and close contacts where by it can be saved. Ensure that they know how to use it. Right after naloxone is presented, you need to get crisis enable instantly. Naloxone is a temporary remedy. Repeat doses could possibly be necessary.
Propulsive peristaltic waves inside the colon are decreased, whilst tone might be improved to the point of spasm leading to constipation. Other opioid-induced consequences may possibly include things like a discount in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase.
Tend not to flush drugs down the rest room or pour them right into a drain unless instructed to do so. Thoroughly discard this item when it is actually expired or now not necessary. Speak to your pharmacist or area waste disposal company.
When useful for an prolonged time, this medication may not work also and may call for unique dosing. Talk with your health care provider if this medication stops Functioning properly.
Drug interactions may possibly improve how your medications get the job done or boost your hazard for major Uncomfortable side effects. This doc does not have all attainable drug interactions.